TRIS 473ml PROMETHAZINE HYDROCHLORIDE AND CODEINE PHOSPHATE ORAL SOLUTION

Tris a brand name for a cough syrup that contains codeine phosphate as its active ingredient. Codeine is an opioid medication that is used to relieve cough symptoms. It works by suppressing the cough reflex in the brain. Tris 473ml Codeine Syrup

This product is commonly used to treat dry, irritating coughs that do not produce mucus or phlegm. It can help reduce the frequency and intensity of coughing, providing temporary relief from cough symptoms.

Specifications: Tris Promethazine/Codeine

1. Active Ingredients

Each 5 mL (one teaspoonful) typically contains:

Promethazine Hydrochloride: 6.25 mg (H1 receptor antagonist/sedative).
Codeine Phosphate: 10 mg (Opioid agonist/cough suppressant).

2. Physical Characteristics

Volume: 473 mL (16 fl oz / 1 Pint).
Dosage Form: Oral Solution (Syrup).¹
Color/Appearance: Typically a clear, peach or light-purple-tinted liquid (depending on the specific manufacturer’s formulation, though Tris is known for a specific peach/fruit flavor profile).
Flavor: Often described as fruit or menthol-infused to mask the bitterness of the active alkaloids.

3. Pharmacological Actions

Component	Function	Mechanism
Codeine	Antitussive	Depresses the cough reflex center in the medulla oblongata.
Promethazine	Antihistamine	Competitively blocks H1 receptor sites; provides sedation and anti-emetic effects.

Clinical Usage and Safety

This medication is indicated for the temporary relief of coughs and upper respiratory symptoms associated with allergies or the common cold in adults and children 18 years of age and older.

Critical Safety Warnings

Black Box Warning: There is a high risk of respiratory depression and death, particularly in children.² It is strictly contraindicated for pediatric patients under 12, and generally avoided in those under 18.
Abuse Potential: Due to the codeine content, this product has a high potential for misuse, addiction, and overdose.³
Drug Interactions: Must not be combined with alcohol, benzodiazepines, or other CNS depressants, as this can lead to fatal respiratory failure.
Common Side Effects: Drowsiness, dizziness, constipation, nausea, and blurred vision.

Storage and Handling

Temperature: Store at controlled room temperature, typically 20°C to 25°C (68°F to 77°F).⁴
Light Sensitivity: Dispense in a tight, light-resistant container to prevent degradation of the promethazine.⁵
Legal Status: Requires a valid DEA-compliant prescription.

Colour: Purple

Tris 473ml Codeine Syrup