Codipront 90ml Codeine Syrup (Portugal)

OVERVIEW

Codipront 90ml Codeine Syrup

Codipront 90ml Codeine Syrup, 2.22 mg/ml + 0.733 mg/ml, syrup
2.
QUALITATIVE AND QUANTITATIVE COMPOSITION
935 – 1 205 mg of codeine-poly (styrene, divinylbenzene)-sulfonate,
equivalent to 200 mg of codeine.
148.5 – 194 mg of phenyltoloxamine-poly (styrene,
divinylbenzene)-sulfonate, equivalent to 66 mg of
phenyltoloxamine.
Excipient(s) with known effect
Each millilitre of syrup contains 2.3 mg of methyl
parahydroxybenzoate;
Each millilitre of syrup contains 1.0 mg of propyl
parahydroxybenzoate;
Each millilitre of syrup contains 383.34 mg of sorbitol (as sorbitol
70% solution);
Each millilitre of syrup contains 0.87 mg of potassium (as potassium
chloride).
Each millilitre of syrup contains 0.36 mg of sodium.
For the full list of excipients, see section 6.1.

PHARMACEUTICAL FORM
Syrup

THERAPEUTIC INDICATIONS
Codipront is recommended for the symptomatic relief of acute dry
irritating cough in adults and
children over 12 years of age.

POSOLOGY AND METHOD OF ADMINISTRATION
Posology and duration of treatment depend on the basic disease, as
well as on the intensity and
frequency of cough. The patient should follow the attending physician
instructions.
Duration of treatment:
The duration of treatment is defined by the doctor

Product Overview

 Composition & Active Ingredients

Codipront utilizes an ion-exchange resin technology to release the active ingredients slowly over time.¹ The following concentrations are standard per 5 mL of syrup:

• Codeine (as Codeine Resin Complex): Equivalent to 20 mg of Codeine Phosphate. It acts on the central nervous system to increase the cough threshold.

• Phenyltoloxamine (as Phenyltoloxamine Resin Complex): Equivalent to 10 mg of Phenyltoloxamine Citrate. This is an antihistamine with mild sedative properties that enhances the antitussive effect.

Note: If the bottle is labeled Codipront Cum Expectorant, it also contains Guaifenesin to help thin and loosen mucus.²

 Dosage and Administration

Due to the sustained-release nature of the resin complex, the effects typically last 10 to 12 hours.

Maximum daily dose for adults should not exceed 10 mL.

Clinical Specifications

• Mechanism of Action: The codeine resin complex provides a slow release in the gastrointestinal tract, ensuring a constant plasma level of codeine.

• Metabolism: Primarily metabolized in the liver via the CYP2D6 enzyme into morphine.

• Duration of Action: Approximately 10–12 hours per dose.

 Safety & Warnings

• Respiratory Depression: Codeine is an opioid; high doses or use in sensitive individuals (especially “Ultra-rapid metabolizers”) can cause slowed breathing.³

• Dependence: Potential for physical and psychological dependence with prolonged use.

• Drowsiness: May cause significant impairment of the ability to drive or operate machinery.

• Contraindications: Do not use if you have asthma, respiratory failure, or are in a “comatose state.” It is strictly contraindicated for children who have undergone tonsillectomy or adenoidectomy for obstructive sleep apnea.

• Alcohol Interaction: Alcohol significantly increases the sedative effect and the risk of respiratory depression.⁴

Storage: Store at room temperature (below 30°C). Shake the bottle well before each use to ensure the resin complex is evenly distributed.

Would you like me to provide a list of common drug interactions for Codipront, such as with MAO inhibitors or other CNS depressants?

Codipront 90ml Codeine Syruphttps://ndbud.com/