OVERVIEW
Kyorin GX 120ml Codeine Syrup
Kyorin GX 120ml Codeine Syrup Ingredients
⁃ Dihydrocodeine Phosphate 2.5mg
⁃ dl-Methyl ephedrine Hydrochloride 6.25mg
⁃ Potassium guaiacol Sultanate 22.5mg
⁃ Chlorpheniramine Maleate 1.00mg
⁃ Anhydrous Caffeine 5mg
⁃ citric acid hydrate as an additive
⁃ Na citrate hydrate, white sugar, high fructose syrup, and containing parabens, benzoic acid Na, dehydroacetic acid Na, caramel, flavors, ethanol, ethyl vanillin, vanillin
The Kyorin GX 120ml Codeine Syrup (officially marketed as Cool One Cough Suppressant GX Liquid) is a specialized cough medication produced by Kyorin Pharmaceutical Co., Ltd.1 in Japan. It is notable for being one of the first Japanese OTC cough medicines to include L-carbocysteine alongside traditional antitussives.2
Below are the detailed technical specifications for this product.
## Product Overview
| Feature | Details |
| Official Name | Cool One Cough Suppressant GX Liquid (クールワンせき止めGX液) |
| Manufacturer | Kyorin Pharmaceutical Co., Ltd. (Japan) |
| Volume | 120 mL |
| Drug Class | Designated Class 2 OTC Drug (Japan) |
| Primary Use | Suppression of persistent cough and thinning of phlegm (sputum) |
Qualitative & Quantitative Composition
The formulation is designed to address both the cough reflex and the physical obstruction of mucus. The following ingredients are typically contained in a 30 mL volume:
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L-Carbocysteine (750 mg):3 A mucolytic agent that repairs the mucosal lining of the throat and thins thick phlegm to make it easier to expel.
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Dihydrocodeine Phosphate (15 mg):4 A narcotic cough suppressant that acts directly on the cough center in the brain.
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dl-Methylephedrine Hydrochloride (37.5 mg):5 A bronchodilator that expands the airways to ease breathing.
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Chlorpheniramine Maleate (6 mg):6 An antihistamine that reduces coughing caused by allergies and irritation.
Note: This specific “GX” version often excludes caffeine, making it distinct from many other Japanese cough syrups (like Bron) that include it as a stimulant.
Dosage and Administration
The syrup is intended for oral use, ideally three times a day after meals.7 If necessary, it can be taken up to six times a day with at least 4 hours between doses.
| Age Group | Single Dose |
| Adults (15+ years) | 5 mL |
| Children (12–14 years) | 3.3 mL |
| Children under 12 | DO NOT USE |
Safety & Precautions
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Respiratory Warning: Due to the dihydrocodeine content, this product is strictly prohibited for children under 12 due to the risk of severe respiratory depression.8
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Drowsiness: The antihistamine component causes significant sleepiness. Do not drive, operate heavy machinery, or perform tasks requiring high alertness after use.9
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Interactions: Do not take this with other cold medicines, sedatives, or oral antihistamines (rhinitis or motion sickness drugs).10
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Breastfeeding: Mothers should avoid this product or stop breastfeeding while using it, as ingredients can pass into breast milk and affect the infant.11
Storage: Keep the bottle tightly closed in a cool, dark place (away from direct sunlight). Use the provided measuring cup for accurate dosing.
Would you like me to compare the “Cool One GX” liquid with the “Cool One GX Plus” tablets to see which fits your needs better?
Colour: Brown, Yellow

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